Genetic Clues for Skin Cancer Therapies Wantagh NY

Scientists have isolated a group of genetic mutations involved in the growth of melanoma, the deadliest form of skin cancer. Their work may lead to therapies with existing drugs that target the same mutations. Led by Yardena Samuels of the National Human Genome Research Institute, the research team from the U.S. National Institutes of Health (NIH) sequenced the protein tyrosine kinase (PTK) gene family in tumor and blood samples from people with metastatic melanoma.

Local Companies

Barry Lipnick
(718) 670-6400
140-15 Sanford Ave
Flushing, NY
Ronny Herskovits
(631) 243-1313
505 Grand Blvd
Deer Park, NY
Karen Green
(631) 367-5395
241 E Main St
Huntington, NY
Marvin Lepaw
(516) 364-9333
155 Froehlich Farm Blvd
Woodbury, NY
Raymond A Havrilla
(516) 931-5588
100 Newbridge Rd # 5
Hicksville, NY
Helen S Flamenbaum
(516) 354-6868
3003 New Hyde Park Rd # 306
New Hyde Park, NY
Carl Leichter
(516) 432-7124
303 E Park Ave # E
Long Beach, NY
Jacqueline Fern
(631) 462-2300
283 Commack Rd # 115
Commack, NY
Joseph Cavallo
(516) 921-7048
50 Underhill Blvd
Syosset, NY
Noam Glaser
(516) 681-4460
146 Manetto Hill Rd
Plainview, NY
Data Provided by:
  

Provided By:

MONDAY, Aug. 31 (HealthDay News) -- Scientists have isolated a group of genetic mutations involved in the growth of melanoma, the deadliest form of skin cancer. Their work may lead to therapies with existing drugs that target the same mutations.

Led by Yardena Samuels of the National Human Genome Research Institute, the research team from the U.S. National Institutes of Health (NIH) sequenced the protein tyrosine kinase (PTK) gene family in tumor and blood samples from people with metastatic melanoma. Their study is published in the September issue of the journal Nature Genetics.

"We have found what appears to be an Achilles' heel of a sizable share of melanomas," Samuels, an investigator in the cancer genetics branch of the institute's Division of Intramural Research, said in a NIH news release.

The PTK family includes many genes that, when mutated, promote many types of cancer, including brain, gastric and lung malignancies, according to background information provided in the news release. In the new NIH study, one PTK gene that appeared particularly suspicious was the ERBB4 gene. Scientists found ERBB4 mutations in 19 percent of patients' tumors, making it the most frequently mutated PTK gene in melanoma. Additional lab studies found that melanoma cells with the ERBB4 defect were dependent on the mutant gene for their growth.

The researchers also found that two additional PTK genes -- FLT1 and PTK2B -- were mutated in about 10 percent of the tumor samples.

The discoveries could open up new avenues for therapies. For example, the researchers discovered that melanoma cells grew much more slowly when exposed to lapatinib (Tykerb), a chemotherapy drug that inhibits ERBB4. Lapatinib is already in use by some breast cancer patients. The NIH team is planning a clinical trial using lapatinib in patients with metastatic melanoma harboring ERBB4 mutations.

"Though additional work is needed to gain a more complete understanding of these genetic mutations and their roles in cancer biology, our findings open the door to pursuing specific therapies that may prove useful for the treatment of melanoma with ERBB4 mutations," Samuels stated.

More information

The American Cancer Society has more on melanoma.

SOURCE: U.S. National Institutes of Health, news release, Aug. 30, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com

Related Articles
- Risk Factors for Squamous Cell Cancer of the Skin Wantagh NY
Squamous cell carcinoma of the skin has multiple risk factors, but the greatest risk factor is sun exposure. Sun: For those who have a long history of sun exposure, the risk of SCC is very high. Individuals who have lived in the Southern USA have a greater chance of developing SCC than those who live in the Northern parts of the country. Worldwide, SCC is again more common in the sunny areas.
- High Levels of Selenium Decreases Incidence of Skin Cancer. Wantagh NY
- Follow Up After Skin Cancer Wantagh NY
- Risks for Childhood Cancer Survivors Wantagh NY
- Breast Cancer Treatment Wantagh NY
- Filling in Wrinkles with Dermal Fillers Wantagh NY
- Delayed Prostate Cancer Therapy Wantagh NY
- Healing Facial Spider Veins Wantagh NY
- Getting a Botox Cosmetic Injection Wantagh NY
- Gene Mutation in Dogs Wantagh NY