Genetic Clues for Skin Cancer Therapies Queens Village NY

Scientists have isolated a group of genetic mutations involved in the growth of melanoma, the deadliest form of skin cancer. Their work may lead to therapies with existing drugs that target the same mutations. Led by Yardena Samuels of the National Human Genome Research Institute, the research team from the U.S. National Institutes of Health (NIH) sequenced the protein tyrosine kinase (PTK) gene family in tumor and blood samples from people with metastatic melanoma.

Local Companies

Bruce Heller
(212) 245-8123
315 W 57Th St # Ll3
New York, NY
Rebecca Baxt
(212) 562-3451
462 1st Ave
New York, NY
Richard Granstein
(212) 746-7274
525 East 68th Street Suite F342
New York, NY
Anne Hardick-Dacko
(212) 844-8800
10 Union Sq E 2A
New York, NY
De Anne Collier
(516) 731-6505
4277 Hempstead Tpke
Bethpage, NY
Hyun-Soo Lee
(201) 886-9000
370 Grand Avenue
Englewood, NJ
Alvin Kien
(212) 263-7380
530 1st Ave
New York, NY
Gregory Bishop
(212) 688-5882
60 East 56th Street 2nd Floor
New York, NY
Carmen Garcia
(212) 749-1820
110 W 97Th St
New York, NY
Tobi Klar
(914) 636-2039
150 Lockwood Ave # 20
New Rochelle, NY
Data Provided by:
  

Provided By:

MONDAY, Aug. 31 (HealthDay News) -- Scientists have isolated a group of genetic mutations involved in the growth of melanoma, the deadliest form of skin cancer. Their work may lead to therapies with existing drugs that target the same mutations.

Led by Yardena Samuels of the National Human Genome Research Institute, the research team from the U.S. National Institutes of Health (NIH) sequenced the protein tyrosine kinase (PTK) gene family in tumor and blood samples from people with metastatic melanoma. Their study is published in the September issue of the journal Nature Genetics.

"We have found what appears to be an Achilles' heel of a sizable share of melanomas," Samuels, an investigator in the cancer genetics branch of the institute's Division of Intramural Research, said in a NIH news release.

The PTK family includes many genes that, when mutated, promote many types of cancer, including brain, gastric and lung malignancies, according to background information provided in the news release. In the new NIH study, one PTK gene that appeared particularly suspicious was the ERBB4 gene. Scientists found ERBB4 mutations in 19 percent of patients' tumors, making it the most frequently mutated PTK gene in melanoma. Additional lab studies found that melanoma cells with the ERBB4 defect were dependent on the mutant gene for their growth.

The researchers also found that two additional PTK genes -- FLT1 and PTK2B -- were mutated in about 10 percent of the tumor samples.

The discoveries could open up new avenues for therapies. For example, the researchers discovered that melanoma cells grew much more slowly when exposed to lapatinib (Tykerb), a chemotherapy drug that inhibits ERBB4. Lapatinib is already in use by some breast cancer patients. The NIH team is planning a clinical trial using lapatinib in patients with metastatic melanoma harboring ERBB4 mutations.

"Though additional work is needed to gain a more complete understanding of these genetic mutations and their roles in cancer biology, our findings open the door to pursuing specific therapies that may prove useful for the treatment of melanoma with ERBB4 mutations," Samuels stated.

More information

The American Cancer Society has more on melanoma.

SOURCE: U.S. National Institutes of Health, news release, Aug. 30, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com

Related Articles
- Risk Factors for Squamous Cell Cancer of the Skin Queens Village NY
Squamous cell carcinoma of the skin has multiple risk factors, but the greatest risk factor is sun exposure. Sun: For those who have a long history of sun exposure, the risk of SCC is very high. Individuals who have lived in the Southern USA have a greater chance of developing SCC than those who live in the Northern parts of the country. Worldwide, SCC is again more common in the sunny areas.
- Healing Facial Spider Veins Queens Village NY
- Follow Up After Skin Cancer Queens Village NY
- Risks for Childhood Cancer Survivors Queens Village NY
- Gene Mutation in Dogs Queens Village NY
- Breast Cancer Treatment Queens Village NY
- Getting a Botox Cosmetic Injection Queens Village NY
- High Levels of Selenium Decreases Incidence of Skin Cancer. Queens Village NY
- Filling in Wrinkles with Dermal Fillers Queens Village NY
- Delayed Prostate Cancer Therapy Queens Village NY