Fungal Infection Treatments Long Beach NY

A drug used to help prevent recurring breast cancer appears to hold promise as a treatment for deadly fungal infections in Long Beach.

Local Companies

Monique M DeFour Jones, MD
(516) 869-8071
444 Community Dr
Manhasset, NY
Tuvia Marciano
(718) 270-1000
450 Clarkson Ave # 49
Brooklyn, NY
Stuart Bitterman
(516) 889-3980
206 W Park Ave
Long Beach, NY
New York Veterinary Specialty Center
(631) 694-3400
2233 Broadhollow Rd
Farmingdale, NY
Ilan Israeli
(516) 433-1888
700 Old Country Rd # 202
Plainview, NY
Jay Gendal
(516) 487-4433
833 Northern Blvd # 100
Great Neck, NY
Barry Kaplan
(516) 470-7330
27005 76Th Ave
New Hyde Park, NY
Sterling Jonas
(718) 434-1140
55 Atlantic Avenue
Brooklyn, NY
Mathew Chengot
(516) 598-3434
129 Broadway
Amityville, NY
Gary Levine
(516) 364-8780
99 Cold Spring Road
Syosset, NY
Data Provided by:
  

Provided By:

A drug used to help prevent recurring breast cancer appears to hold promise as a treatment for deadly fungal infections, new research has found.

University of Rochester Medical Center researchers found that tamoxifen kills yeast in mice with Candida infections, which can be fatal to people with compromised immune systems, including people with cancer or HIV and those taking immunosuppressants for chronic conditions.

At extremely high levels, tamoxifen slashed yeast levels by 150-fold, causing most fungus cells to break up and die while halting surviving cells from progressing into a disease-causing state, their study found.

"It's still early, but if tamoxifen, or molecules like it, turns out to be an effective treatment against serious fungal infections, it'll be a welcome addition to our arsenal," Dr. Damian Krysan, an assistant professor of pediatrics at the university and an author of the study, said in a university news release.

The results are published in the August issue of Antimicrobial Agents and Chemotherapy.

Available antifungal medications pose some issues for people who need them the most, according to background information in the news release. The only new class of antifungals approved for use in the past two decades is generally effective, but they can only be taken intravenously, which poses logistic and other problems for some patients. And the most common oral antifungal medication only slows fungus cell growth, making it difficult for immune-compromised patients to completely shake their infections.

"We don't have vaccines against fungal infections, and the few drugs we do have aren't always effective," Krysan said. "We've got a lot more work to do to figure out whether tamoxifen could be used in high doses or whether it could be used in combination with other treatments, but we're excited about the possibility of giving doctors another way to help these critically ill patients."

More information

The U.S. Centers for Disease Control and Prevention has more about Candidiasis.

SOURCE: University of Rochester Medical Center, news release, July 20, 2009

Copyright © 2009 ScoutNews, LLC. All rights reserved.

Read Article at HealthDay.com